“Double-hit” of DUSP22 and TP63 rearrangements in anaplastic large cell lymphoma, ALK-negative

ALK- negative Anaplastic Large Cell Lymphoma of Bone

alk- negative anaplastic large cell lymphoma of bone

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ALK-negative anaplastic large-cell lymphoma.

Pathobiology of ALK-negative anaplastic large cell lymphoma

The authors revise the concept of ALK-negative anaplastic large cell lymphoma (ALCL) in the light of the recently updated WHO classification of Tumors of Hematopoietic and Lymphoid Tissues both on biological and clinical grounds. The main histological findings are illustrated as well as the phenotypic, molecular and clinical characteristics. Finally, the biological rationale for possible innova...

ALK- negative Anaplastic Large Cell Lymphoma of Bone

Introduction Primary bone lymphoma (PBL) is a rare disease that was first described by Oberling in 1928.1 The vast majority of PBL cases are non-Hodgkin lymphoma (NHL), whereas primary Hodgkin lymphoma (HL) of bone is extremely rare. PBL constitutes 7% of all malignant bone tumors, 4-5% of all extranodal NHL, and less than 1% of all malignant lymphomas.2-5 Patients with primary NHL of bone comm...